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nlrp3 specific antagonist mcc950  (ApexBio)

 
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    Structured Review

    ApexBio nlrp3 specific antagonist mcc950
    EA's anti-allodynic effect on CPIP rats is mimicked by pharmacological blocking NLRP3 inflammasome. (A) Experimental protocol. (B) 50% PWT following EA or <t>MCC950</t> intervention (30 μg/rat/day, i.t.). (C) Normalized AUC deduced from (B) . (D) Immunostaining showing the effect of EA/MCC950 intervention on astrocyte (Upper panels, marked with GFAP) and microglia overactivation in SCDH. (E,F) Summary of the mean fluorescence intensity of GFAP (E) and OX42 (F) , normalized with the value of sham group. n = 5 rats/group. Scale bar indicates 100 μm. ** p < 0.01 # p < 0.05, ## p < 0.01. Two-way ANOVA with Tukey's post-hoc test was applied in panel B. One-way ANOVA with Tukey's post-hoc test was applied in (C,E,F) . NS, no significance.
    Nlrp3 Specific Antagonist Mcc950, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nlrp3+specific+antagonist+mcc950/pmc09174662-54-0-11?v=ApexBio
    Average 90 stars, based on 1 article reviews
    nlrp3 specific antagonist mcc950 - by Bioz Stars, 2026-07
    90/100 stars

    Images

    1) Product Images from "Electroacupuncture Ameliorates Mechanical Allodynia of a Rat Model of CRPS-I via Suppressing NLRP3 Inflammasome Activation in Spinal Cord Dorsal Horn Neurons"

    Article Title: Electroacupuncture Ameliorates Mechanical Allodynia of a Rat Model of CRPS-I via Suppressing NLRP3 Inflammasome Activation in Spinal Cord Dorsal Horn Neurons

    Journal: Frontiers in Cellular Neuroscience

    doi: 10.3389/fncel.2022.826777

    EA's anti-allodynic effect on CPIP rats is mimicked by pharmacological blocking NLRP3 inflammasome. (A) Experimental protocol. (B) 50% PWT following EA or MCC950 intervention (30 μg/rat/day, i.t.). (C) Normalized AUC deduced from (B) . (D) Immunostaining showing the effect of EA/MCC950 intervention on astrocyte (Upper panels, marked with GFAP) and microglia overactivation in SCDH. (E,F) Summary of the mean fluorescence intensity of GFAP (E) and OX42 (F) , normalized with the value of sham group. n = 5 rats/group. Scale bar indicates 100 μm. ** p < 0.01 # p < 0.05, ## p < 0.01. Two-way ANOVA with Tukey's post-hoc test was applied in panel B. One-way ANOVA with Tukey's post-hoc test was applied in (C,E,F) . NS, no significance.
    Figure Legend Snippet: EA's anti-allodynic effect on CPIP rats is mimicked by pharmacological blocking NLRP3 inflammasome. (A) Experimental protocol. (B) 50% PWT following EA or MCC950 intervention (30 μg/rat/day, i.t.). (C) Normalized AUC deduced from (B) . (D) Immunostaining showing the effect of EA/MCC950 intervention on astrocyte (Upper panels, marked with GFAP) and microglia overactivation in SCDH. (E,F) Summary of the mean fluorescence intensity of GFAP (E) and OX42 (F) , normalized with the value of sham group. n = 5 rats/group. Scale bar indicates 100 μm. ** p < 0.01 # p < 0.05, ## p < 0.01. Two-way ANOVA with Tukey's post-hoc test was applied in panel B. One-way ANOVA with Tukey's post-hoc test was applied in (C,E,F) . NS, no significance.

    Techniques Used: Blocking Assay, Immunostaining, Fluorescence



    Similar Products

    nlrp3 specific antagonist mcc950  (ApexBio)
    90
    ApexBio nlrp3 specific antagonist mcc950
    EA's anti-allodynic effect on CPIP rats is mimicked by pharmacological blocking NLRP3 inflammasome. (A) Experimental protocol. (B) 50% PWT following EA or <t>MCC950</t> intervention (30 μg/rat/day, i.t.). (C) Normalized AUC deduced from (B) . (D) Immunostaining showing the effect of EA/MCC950 intervention on astrocyte (Upper panels, marked with GFAP) and microglia overactivation in SCDH. (E,F) Summary of the mean fluorescence intensity of GFAP (E) and OX42 (F) , normalized with the value of sham group. n = 5 rats/group. Scale bar indicates 100 μm. ** p < 0.01 # p < 0.05, ## p < 0.01. Two-way ANOVA with Tukey's post-hoc test was applied in panel B. One-way ANOVA with Tukey's post-hoc test was applied in (C,E,F) . NS, no significance.
    Nlrp3 Specific Antagonist Mcc950, supplied by ApexBio, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nlrp3+specific+antagonist+mcc950/pmc09174662-54-0-11?v=ApexBio
    Average 90 stars, based on 1 article reviews
    nlrp3 specific antagonist mcc950 - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    EA's anti-allodynic effect on CPIP rats is mimicked by pharmacological blocking NLRP3 inflammasome. (A) Experimental protocol. (B) 50% PWT following EA or MCC950 intervention (30 μg/rat/day, i.t.). (C) Normalized AUC deduced from (B) . (D) Immunostaining showing the effect of EA/MCC950 intervention on astrocyte (Upper panels, marked with GFAP) and microglia overactivation in SCDH. (E,F) Summary of the mean fluorescence intensity of GFAP (E) and OX42 (F) , normalized with the value of sham group. n = 5 rats/group. Scale bar indicates 100 μm. ** p < 0.01 # p < 0.05, ## p < 0.01. Two-way ANOVA with Tukey's post-hoc test was applied in panel B. One-way ANOVA with Tukey's post-hoc test was applied in (C,E,F) . NS, no significance.

    Journal: Frontiers in Cellular Neuroscience

    Article Title: Electroacupuncture Ameliorates Mechanical Allodynia of a Rat Model of CRPS-I via Suppressing NLRP3 Inflammasome Activation in Spinal Cord Dorsal Horn Neurons

    doi: 10.3389/fncel.2022.826777

    Figure Lengend Snippet: EA's anti-allodynic effect on CPIP rats is mimicked by pharmacological blocking NLRP3 inflammasome. (A) Experimental protocol. (B) 50% PWT following EA or MCC950 intervention (30 μg/rat/day, i.t.). (C) Normalized AUC deduced from (B) . (D) Immunostaining showing the effect of EA/MCC950 intervention on astrocyte (Upper panels, marked with GFAP) and microglia overactivation in SCDH. (E,F) Summary of the mean fluorescence intensity of GFAP (E) and OX42 (F) , normalized with the value of sham group. n = 5 rats/group. Scale bar indicates 100 μm. ** p < 0.01 # p < 0.05, ## p < 0.01. Two-way ANOVA with Tukey's post-hoc test was applied in panel B. One-way ANOVA with Tukey's post-hoc test was applied in (C,E,F) . NS, no significance.

    Article Snippet: NLPR3 specific antagonist MCC950 and the activator nigericin were purchased from APExBIO Technology (USA).

    Techniques: Blocking Assay, Immunostaining, Fluorescence